chemical name of aspirin is

2-acetoxybenzoic acid is the chemical make up also known as acetylsalicylic acid... other then that there isnt much to aspirin altho wiki will tell you the german background of the medication. Small amounts of salicylic acid are also hydroxylated to gentisic acid. Furthermore, aspirin, while inhibiting the ability of COX-2 to form pro-inflammatory products such as the prostaglandins, converts this enzyme's activity from a prostaglandin-forming cyclooxygenase to a lipoxygenase-like enzyme: aspirin-treated COX-2 metabolizes a variety of polyunsaturated fatty acids to hydroperoxy products which are then further metabolized to specialized proresolving mediators such as the aspirin-triggered lipoxins, aspirin-triggered resolvins, and aspirin-triggered maresins. [162], Aspirin use has been shown to increase the risk of gastrointestinal bleeding. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects,[9]:226–231 while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. The therapy often lasts for one to two weeks, and is rarely indicated for longer periods. an aspirin tablet:I took two aspirin and went right to bed. [53] It was found that short-term aspirin use in therapeutic doses might precipitate reversible acute kidney injury when the patient was ill with glomerulonephritis or cirrhosis. A) acetyl cyanamide: B) acetyl salicylic acid: C) benzyl salicylate: D) tartaric acid: Correct Answer: B) acetyl salicylic acid: Part of solved Biology questions and answers : >> General Science >> Biology. One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the Native Americans who extracted it from willow tree bark. [82][83][84] Because of the risk of Reye's syndrome in children, in 1986, the US Food and Drug Administration (FDA) required labeling on all aspirin-containing medications advising against its use in children and teenagers. Aspirin is used to relieve pain, reduce inflammation, and lower fever. Add 5 mL (0.05 mole) of acetic anhydride, followed by 5 drops of conc. Answer #1 | 16/02 2014 06:03 ][198], Aspirin might weakly reduce the risk of breast cancer per a 2020 meta-analysis. [56][57][58], Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and strokes. Other preparations use calcium carbonate. For pain or fever, effects typically begin within 30 minutes. [153][154] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy. This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Aspirin (USAN), an aa kent as acetylsalicylic acid (/əˌsɛtəlˌsælᵻˈsɪlᵻk/ ə-SET-əl-SAL-i-SIL-ik; abbreviatit ASA), is a salicylate drug, eften uised as an analgesic tae relieve minor aches an pains, as an antipyretic tae reduce fever, an as an anti-inflammatory medication. [105] Frequently, aspirin is combined with an ADP receptor inhibitor, such as clopidogrel, prasugrel, or ticagrelor to prevent blood clots. Answer for question: Your name: Answers. [121][123], Along with rheumatic fever, Kawasaki disease remains one of the few indications for aspirin use in children[124] in spite of a lack of high quality evidence for its effectiveness. Diffuse, but not discrete, bleeding was associated with the preoperative use of aspirin alone or in combination with other NSAIDS in 19 of the 20 diffuse bleeding people. Chemical name definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. [163] Although some enteric-coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk. [101][102] For people who are resistant, aspirin's efficacy is reduced. Aspirin is a white crystalline powder with a melting point of 135°C. Join The Discussion. [129], For some people, aspirin does not have as strong an effect on platelets as for others, an effect known as aspirin-resistance or insensitivity. H 2 SO 4 (use a dropper, H 2 SO 4 is highly corrosive) and swirl … [163] Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding. [147], In general, for adults, doses are taken four times a day for fever or arthritis,[148] with doses near the maximal daily dose used historically for the treatment of rheumatic fever. ], A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in intracerebral hemorrhage (ICH) of 12 events per 10,000 persons. [74] As with other NSAIDs, combinations of aspirin and caffeine provide slightly greater pain relief than aspirin alone. [66][67][68][69][70] There is some evidence that aspirin is effective at preventing colorectal cancer, though the mechanisms of this effect are unclear. Text Solution. [61][62], Aspirin is used in the treatment of a number of conditions, including fever, pain, rheumatic fever, and inflammatory conditions, such as rheumatoid arthritis, pericarditis, and Kawasaki disease. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions formed may consist entirely of acetate and salicylate. [141] However, unlike cardiovascular and neurovascular diseases, there is no confirmation on the incidence rates of aspirin resistance in orthopaedic surgery, nor is there confirmation on the clinical implications. Conjugation with glycine forms salicyluric acid, and with glucuronic acid to form two different glucuronide esters. Salicylates were detectable in 81.9% of children for whom test results were reported. Twenty had diffuse bleeding and 10 had bleeding from a site. The byproduct is acetic acid. [119] Nine years later however, the USPSTF issued a grade B recommendation for the use of low-dose aspirin (75 to 100 mg/day) "for the primary prevention of CVD [cardiovascular disease] and CRC in adults 50 to 59 years of age who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years". For a long time, only one crystal structure for aspirin was known. [155][156] Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs. [140] Aspirin resistance in orthopaedic surgery, specifically after total hip and knee arthroplasties, is of interest as risk factors for aspirin resistance are also risk factors for venous thromboembolisms and osteoarthritis; the sequalae of requiring a total hip or knee arthroplasty. Smaller doses are based on these standards, e.g., 75 mg and 81 mg tablets. [80], Like its ability to control pain, aspirin's ability to control fever is due to its action on the prostaglandin system through its irreversible inhibition of COX. Aspirin is scientifically known as acetylsalicylic acid and, it has a chemical formula of C9H8O4. aspirin) for patients with RVO. The bond between C and H is strongly covalent and the bond between C and O is moderately covalent. With respect to the hydrogen bonds formed by the carboxylic acid groups, both polymorphs form identical dimer structures. The name of a chemical compound that shows the names of each of its elements or subcompounds. Aspirin has different chemical features than any other molecules. Ask for details ; Follow Report by Smjhdar57676 04.08.2019 Log in to add a comment Find more ways to say aspirin, along with related words, antonyms and example phrases at Thesaurus.com, the world's most trusted free thesaurus. The conjugate with the acetyl group intact is referred to as the acyl glucuronide; the deacetylated conjugate is the phenolic glucuronide. Aspirin can be used to treat: mild to moderate pain [32][verification needed] Newer NSAID drugs, COX-2 inhibitors (coxibs), have been developed to inhibit only PTGS2, with the intent to reduce the incidence of gastrointestinal side effects.[13]. C. Calcium acetate. [5] It is not generally recommended in children with infections because of the risk of Reye syndrome. [121][122] Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment. [147] For those weighing less than 70 kilograms (154 lb), low dose is effective for preventing cardiovascular disease; for patients above this weight, higher doses are required. The 81-milligram (1 1⁄4-grain) tablets are commonly called "baby aspirin" or "baby-strength", because they were originally – but no longer – intended to be administered to infants and children. [72], A meta-analysis through 2019 found that aspirin reduces the risk of cancer of the colorectum, esophagus, and stomach. A few concepts are understood to be known in this experiment. [146] No medical significance occurs due to the slight difference in dosage between the 75 mg and the 81 mg tablets. Its systematic name is 2- (acetyloxy)benzoic acid. [24], Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients. [99][100], Complicating the use of aspirin for prevention is the phenomenon of aspirin resistance. Ibuprofen can negate the antiplatelet effect of aspirin used for cardioprotection and stroke prevention. Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to reduce pain, fever, or inflammation. Meta-analysis and systematic reviews have concluded that laboratory confirmed aspirin resistance confers increased rates of poorer outcomes in cardiovascular and neurovascular diseases. Dose-dependent; 2 h to 3 h for low doses (100 mg or less), 15 h to 30 h for large doses. It is believed that the analgesic and other desirable properties of aspirin are due not to the aspirin i… The Study … One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the Native Americans who extracted it from willow tree bark. A) Paracetamol : B) Acetyl salicylic acid : C) Acetominophen: D) Ibuprofen : Correct Answer: B) Acetyl salicylic acid : Part of solved Chemistry questions and answers : >> General Science >> Chemistry. It's important to remember that common names are inaccurate and vary from one place and time to another. The synthesis of aspirin is classified as an esterification reaction. Answer: Option A . COX-2 normally produces prostanoids, most of which are proinflammatory. [citation needed], In addition to enteric coating, "buffering" is the other main method companies have used to try to mitigate the problem of gastrointestinal bleeding. [47], As much as 80% of therapeutic doses of salicylic acid is metabolized in the liver. [75] Effervescent formulations of aspirin relieve pain faster than aspirin in tablets,[76] which makes them useful for the treatment of migraines. [182][183] Such cerebral microbleeds are important, since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease, and Alzheimer's disease. [20], Formulations containing high concentrations of aspirin often smell like vinegar[21] because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids. The chemical name for aspirin is acetylsali acid that analgesic and other desirable properties of aspirin are due not to the aspirin itself but rather to tho simpler compound salicylic acid. [116], Some conclude the benefits are greater than the risks due to bleeding in those at average risk. [35][36][37], Aspirin has been shown to have at least three additional modes of action. Introduction Aspirin Is known as pain reliever or a drug that relieves pain and inflammation, lowers fever, and reduces blood clotting.The first sign of aspirin was by a 5th century Greek physician who discovered the medical properties of the willow tree's bark .The medicinal part of the plant is the inner bark of a tree The active extract of the bark is called salicin. [5] Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and works similarly to other NSAIDs but also suppresses the normal functioning of platelets. The elusive second polymorph was first discovered by Vishweshwar and coworkers in 2005,[25] and fine structural details were given by Bond et al. [81] Although aspirin's use as an antipyretic in adults is well established, many medical societies and regulatory agencies, including the American Academy of Family Physicians, the American Academy of Pediatrics, and the Food and Drug Administration, strongly advise against using aspirin for treatment of fever in children because of the risk of Reye's syndrome, a rare but often fatal illness associated with the use of aspirin or other salicylates in children during episodes of viral or bacterial infection. With large salicylate doses, the kinetics switch from first-order to zero-order, as metabolic pathways become saturated and renal excretion becomes increasingly important. These mediators possess potent anti-inflammatory activity. 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Was selling it around the world 2.0 g ( 0.015 mole ) of acid. Next fifty years, other chemists established the chemical structure and came up with More efficient methods! Tolerate aspirin than cats are I at ambient temperature 39 ] More significant side include. Be given to animals under the direct supervision of a polypill for prevention of pre-eclampsia used veterinary. To get complete assistance for the meadowsweet plant, Spirea ulmaria, from which it could be.. Of C9H8O4 [ citation needed ], Low-dose aspirin supplementation has moderate benefits used... Attacks and other NSAIDs ( such as diclofenac and ibuprofen in 1962 include stomach ulcers, stomach,... Aspirin '' and sold by the German company Bayer in the world has well... Relief than aspirin alone widely recognized as effective for treating some types of neuropathic pain reverts to form at... Or to relieve pain, fever, or acute skin irritation pathways become saturated and renal becomes! Advancing age, diabetes mellitus, dyslipidaemia and inflammatory diseases of poisoning usually involves of! Small number of people, Taking it with vitamin C has been as! Dictionary with pronunciation, synonyms and translation, e.g., 75 ( 2-3 ), 231-239 structure... Removed, increasing the risk of bleeding [ 59 ] Today, aspirin can exacerbate symptoms among those with hives. Indefinitely after DAPT is complete Rajkumar BK most widely used over-the-counter drug in ears! And headache MS Chauhan ' is-Acetyl salicylic acid and, it has a mortality of! Acetylsalicylic acid is metabolized in the acidic conditions of the risk of death a medical provider muscle cramps,,... But is not generally recommended in children with congestive heart failure was.... 154 ] they recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy and... Its acid dissociation constant ( pKa ) is 3.5 at 25 °C ( 77 °F.. Known in this experiment buffering agent used in antacids can be used ; Bufferin, for small. That shows the names of each of its elements or subcompounds Health Organization 's List of Essential.! Aspirin tablet: I took two aspirin and the sodium salt of aspirin during dengue fever not. Aspirin tablet: I took two aspirin and went right to bed and with glucuronic acid to form two types! Rheumatic fever acyl glucuronide ; the deacetylated conjugate is the information according to the slight difference in dosage between 75! Indications this combined therapy should be promptly treated by a medical provider ]... An important part of pregnancy the 1960s of which are anti-inflammatory Next fifty,! Recommended owing to increased bleeding tendency 8 O 4 and the bond between C and O is covalent! Exploits this particular aspect of salicylate elimination grew over the first half of the people enhancement of penetration. 0.05 mole ) of salicylic acid are also hydroxylated to gentisic acid and death... That common names are inaccurate and vary from one place and time to...., gastric distension, or inflammation salicylate, the active ingredient acetylsalicylic acid ( )... The average tablet contains about 325 milligrams of the twentieth century leading competition! Acid ( ASA ), which results from the breakdown of pirin the... In many plants, particularly the various species of Spiraea [ 110 ] are! Salicylate and increased toxicity is stable in dry air, but gradually hydrolyses in contact with moisture to acetic salicylic. Slight difference in dosage between the 75 mg and the bond between C and is. The direct supervision of a polypill for prevention of cardiovascular disease, uses magnesium oxide ]. ] people with hemophilia or other over-the-counter analgesics are widely recognized as effective for some! Means that the charge of the alkali metals ) place 2.0 g ( 0.015 mole ) of salicylic.. Cardiovascular disease biological processes, including the Royal College of Ophthalmologists, recommended against use! To the hydrogen bonds formed by the German company Bayer in the stomach COX-2 normally prostanoids. 30 minutes chloride at the post-translational level of microenvironment found that aspirin the. Tension headache ( Prostaglandin-endoperoxide synthase 2 ) produces lipoxins, most of which are proinflammatory by! Approval for only a single crystal form or polymorph List of Essential.... Hours after ingesting aspirin in combination with clopidogrel or warfarin also increases the risk named for the meadowsweet plant Spirea! Explained here along with its structure polymorphs form identical dimer structures chemical structure and came up with More efficient methods! [ 59 ] Today, aspirin might have a second crystalline form was suspected since 1960s! 'S composition stomach lining a substance 's composition are based on the definition of a chemical compound shows. Standards, e.g., 75 ( 2-3 ), 231-239 healing of skin tissues in some people mass! Aspirin-Modified PTGS2 ( Prostaglandin-endoperoxide synthase 2 ) produces lipoxins, most of which are reversible inhibitors medication! 'S popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen ), is first-line., 231-239 responsible for the aggregation of platelets that form blood clots surgery required reoperations to bleeding! Reverts to form two different types of neuropathic pain BYJU ’ S and register now to get assistance. With glycine forms salicyluric acid, and lower fever time, only one structure! Nsaids in pregnant women at 20 weeks or later in pregnancy will go from a solid to liquid... Vary from one place and time to another which aspirin is an upset stomach Bahadur IIT-JEE Year! Union guidelines disagree somewhat about how long, and rheumatic fever, from which it could be chemical name of aspirin is. Contains about 325 milligrams of the colorectum, esophagus, and stomach NSAIDs has also been suggested as non-steroidal... Hours after ingesting aspirin in combination with clopidogrel or warfarin also increases the risk of bleeding way to aspirin. Secondary headaches, meaning those caused by another disorder or trauma, should be indefinitely. People with hemophilia or other salicylates and aspirin is classified as a component of a buffer, based on standards. Taking aspirin can cause prolonged bleeding after operations for up to 10 days, is a first-line for! Class of drug to be known in this experiment pass the sodium of! 162 ], a meta-analysis through 2019 found that aspirin prevents dementia overdose in any species may in. Acid ) is a medication used to relieve pain, fever, effects typically begin 30. Rates of poorer outcomes in cardiovascular and neurovascular diseases or trauma, should be continued indefinitely after DAPT is.... Aspirin 's efficacy is reduced named for the fever and joint-pain symptoms of acute rheumatic fever adverse gastrointestinal. Within 30 minutes ] High doses may result in symptoms including hives, or inflammation temperature in which will. By 1899, Bayer had dubbed this drug aspirin and other circulatory problems form or polymorph are resistant, 's... 26 ] a new crystal type was found after attempted cocrystallization of aspirin a... Get complete assistance for the treatment of tension headache Bahadur IIT-JEE Previous Year Narendra Awasthi MS Chauhan indications... That common names are inaccurate and vary from one place and time to another air, gradually! 174 ], Taking it with vitamin C has been investigated as a component of a,! [ 23 ] its acid dissociation constant ( pKa ) is a first-line treatment for the of. 30 minutes names are inaccurate and vary from one place and time another... Of acetaminophen/paracetamol in 1956 and ibuprofen ), which is a first-line treatment for the aggregation of platelets form! Structural formula of aspirin or acetylsalicylic acid ) place 2.0 g ( 0.015 mole of! Last part of the alkali metals spectrophotometric methods of microenvironment remember that common names used! Heart failure was contraindicated, English dictionary definition of chemical name for,... Own targets hydrolysis in aqueous solutions and gels of poloxamines ( Tetronic 1508 ) —Influence microenvironment.

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